The effects and mechanism of vitamin D deficiency on rupture of cerebral aneurysms

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09412
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Suzuki Kota 浜松医科大学, 医学部附属病院, 助教 (40751631)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 脳動脈瘤 / くも膜下出血 / ビタミンD / マウスモデル

Outline of Final Research Achievements

[Purpose] We hypothesized that VD deficiency increases cerebral aneurysm rupture, and tested it using a mouse cerebral aneurysm model.[Method] (Experiment 1) A cerebral aneurysm was induced in each mouse assigned to the control diet group or the VD-deficient diet group, and the presence or absence of cerebral aneurysm development and rupture was confirmed. (Experiment 2) Verification of the incidence and rupture rate of cerebral aneurysms using vascular endothelial cells, vascular smooth muscle cells, myelocytes-specific vitamin D receptor (VDR) -deficient mice and their littermate normal mice. did.[Results] (Experiment 1) The cerebral aneurysm rupture rate was higher in the VD-deficient diet group than in the control diet group. (Experiment 2) The rupture rate of cerebral aneurysm was high in specific VDR-deficient mice of vascular endothelial cells and vascular smooth muscle cells. There was no difference in myelocyte-specific VDR-deficient mice.

Free Research Field

麻酔科学、救急医学

Academic Significance and Societal Importance of the Research Achievements

マウス脳動脈瘤に置いて、ビタミンD欠乏は脳動脈瘤破裂を増加させた。脳動脈瘤の破裂増加には炎症が関与し、血管内皮細胞と血管平滑筋細胞のビタミンD受容体が重要であることが示唆された。マウス脳動脈瘤に置いて、ビタミンD欠乏は脳動脈瘤破裂を増加させた。脳動脈瘤の破裂増加には炎症が関与し、血管内皮細胞と血管平滑筋細胞のビタミンD受容体が重要であることが示唆された。マウス脳動脈瘤に置いて、ビタミンD欠乏は脳動脈瘤破裂を増加させた。脳動脈瘤の破裂増加には炎症が関与し、血管内皮細胞と血管平滑筋細胞のビタミンD受容体が重要であることが示唆された。