Elucidation of the mechanism of vascular endothelial damage from the viewpoint of glycocalyx in severe burns and establishment of control methods

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K09413
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Osaka University
• Principal Investigator: Osuka Akinori 大阪大学, 大学院医学系研究科, 招へい教員 (60552081)
• Co-Investigator(Kenkyū-buntansha): 松浦 裕司 大阪大学, 医学部附属病院, 医員 (10791709) ; 岡田 英志 岐阜大学, 医学部附属病院, 准教授 (30402176) ; 清水 健太郎 大阪大学, 医学部附属病院, 助教 (60379203) ; 小倉 裕司 大阪大学, 大学院医学系研究科, 准教授 (70301265)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 熱傷 / 外傷 / 血管内皮障害 / グリコカリックス

Outline of Final Research Achievements

Using an animal model, we observed under direct observation the degree of vascular endothelial glycocalyx damage that occurs after severe burn injury and found that vascular endothelial glycocalyx is shed from immediately after burn injury. The degree of shedding and the time required for repair varied from organ to organ. We have also investigated treatment methods to prevent the progression to multiple organ failure by preventing the loss of endothelial glycocalyx using various drugs. rTM was found to be ineffective at low doses, but mortality was reduced at higher doses. Anti-IL6 receptor antibody administration was found to maintain glycocalyx. The mechanism is still being elucidated.

Free Research Field

救急、熱傷、外傷、血管内皮障害、免疫

Academic Significance and Societal Importance of the Research Achievements

グリコカリックスという血管内皮構造を直接視認することにより、重症熱傷受傷後の体液変動のメカニズムの一部を解明した。これにより、今までは重症熱傷により死亡していた患者を救命できる可能性の道筋がみえた。一方で、病態解明は進んだが、制御法については未だ確立されておらず、今後の課題も明らかとなった。