Relationship among delirium, sleep disruption, and light reflex in recovery phase and short term ADL in critically ill patients.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09418
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Yamaguchi University
• Principal Investigator: Tsuruta Ryosuke 山口大学, 大学院医学系研究科, 教授 (30263768)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 集中治療後症候群 / ADL / QOL / 炎症

Outline of Final Research Achievements

[Objective] Patients discharged from the ICU, who were 1) older than 19 years of age, 2) staying for more than 4 days, and 3) obtained consent were included. [Methods] On 90 days after the ICU discharge, we evaluated the patient with or without physical post-intensive care syndrome (P-PICS) by using the SF-36 and compared the several parameters and laboratory data between 2 groups of with/without P-PICS.
[Results] Out of 49 consented, 42 patients were included because of 7 patients without answer of SF-36. Seventy-four percent of 42 patients were P-PICS group. P-PICS group were significantly older than non-P-PICS group [72 (66-76) vs 66 (58-72), p=0.04]. Serum albumin and C-reactive protein levels before ICU discharge in P-PICS group were significantly lower and higher than those in non-P-PICS group, respectively [2.5 (1.9-2.8) vs 3.1(2.6-3.2), p=0.01, 7.2 (2.8-11.0) vs 3.5 (1.2-4.2), p=0.01]. There were no significant differences between the other scores and measurements in 2 groups.

Free Research Field

救急・集中治療

Academic Significance and Societal Importance of the Research Achievements

重症な傷病でICUに入院してきた患者のICU退室前の栄養状態または炎症反応の結果がICUを退室し日常生活に戻った90日目の身体機能を予測できる可能性が判明した。今後は日常診療でICU退室前の血清アルブミンとC反応性蛋白の値に注目していきたい。