2021 Fiscal Year Final Research Report
Study of Advanced Cardiac Life Support for Ventricular Fibrillation with Extracorporeal Circulation in Japan (SAVE J-II study)
| Project/Area Number |
19K09419
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55060:Emergency medicine-related
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
一二三 亨 聖路加国際大学, 聖路加国際病院, 副医長 (30383756)
坂本 哲也 帝京大学, 医学部, 教授 (40365979)
井上 明彦 香川大学, 医学部, 協力研究員 (60835247)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 院外心停止 |
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| Outline of Final Research Achievements |
This is the retrospective large cohort study named SAVE-J II study to provide real-world data on ECPR in Japan including details of clinical data with approximately 2,000 patients. This study aimed to assess patient characteristics, outcomes, and complications of ECPR practice in patients with OHCA.
In this large cohort, data on the ECPR of 1644 patients with OHCA show that the proportion of favorable neurological outcomes at hospital discharge was 14.1% and survival rate at hospital discharge was 27.2%. Complications were observed during ECPR in 32.7% of patients, and the most common complication was bleeding, with the rates of cannulation site bleeding and other types of hemorrhage at 16.4% and 8.5%, respectively.
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| Free Research Field |
神経集中治療
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| Academic Significance and Societal Importance of the Research Achievements |
院外心停止患者の転帰改善、社会復帰率上昇への取り組みは重要課題である。体外式膜型人工肺を組み合わせた心肺蘇生法（ECPR）では、救命率、神経学的転帰の改善が期待されているが、ECPR は侵襲が大きく相当量の医療資源を必要とするため施行可能な施設は限られる。ガイドラインにおいても明確な適応基準や管理方法は決まっておらず、また本邦における実態は不明である。本研究のようなECPRに特化した大規模なレジストリは世界的にもなく、ECPRに関連する十分な症例数のある研究は過去にない。世界的にもないECPRに特化した大規模データで、治療成績、適応、合併症を検討することの重要性は大きい。
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