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2023 Fiscal Year Final Research Report

Exploration of New Therapeutic Targets for Pulmonary Circulatory Dysfunction in ARDS

Research Project

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Project/Area Number 19K09422
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionYokohama City University

Principal Investigator

KANEMARU Eiki  横浜市立大学, 附属病院, 助教 (50793494)

Co-Investigator(Kenkyū-buntansha) 菅原 陽  横浜市立大学, 附属市民総合医療センター, 助教 (00596413)
東條 健太郎  横浜市立大学, 医学部, 講師 (80737552)
Project Period (FY) 2019-04-01 – 2024-03-31
KeywordsARDS / 肺高血圧
Outline of Final Research Achievements

In this study, we analyzed the effects of pre-existing pulmonary hypertension on ARDS using a monocrotaline-induced pulmonary hypertension model. In rats with monocrotaline-induced pulmonary hypertension, some of the inflammatory responses triggered by intratracheal LPS administration were attenuated, and tissue damage was not exacerbated. These findings suggest that in patients with pulmonary hypertension accompanied by inflammation, the immune response in the lungs may be weakened, leading to reduced inflammation but increased susceptibility to infections.

Free Research Field

集中治療医学

Academic Significance and Societal Importance of the Research Achievements

本研究では肺高血圧症がARDSに与える影響について動物モデルを用いて研究を行い、炎症を伴う肺高血圧症モデル動物では、病原体によって引き起こされる炎症反応の一部が減弱していることを明らかすることができた。本研究の成果から、肺高血圧症の患者さんが、肺炎などに対して脆弱であるメカニズムの解明につながることが期待される。

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Published: 2025-01-30  

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