2022 Fiscal Year Final Research Report

Development of new devise of continuous olfactory mucosa stimulation for intraoperative monitoring and treatment of cognitive dysfunction

Research Project

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Project/Area Number	19K09493
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56010:Neurosurgery-related
Research Institution	Kurume University
Principal Investigator	Sakata Kiyohiko 久留米大学, 医学部, 准教授 (90368936)
Co-Investigator(Kenkyū-buntansha)	森岡基浩久留米大学, 医学部, 教授 (20295140) 小牧哲久留米大学, 医学部, 助教 (20597413) 折戸公彦久留米大学, 医学部, 講師 (50597408)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	嗅粘膜刺激 / 鼻腔内刺激電極 / 嗅神経刺激電位 / 高次脳機能障害
Outline of Final Research Achievements	For the purpose of establishing an intraoperative monitoring system for surgeries intended to preserve the olfaction, we developed a stimulation probe that can be placed in the nasal cavity to stimulate the olfactory mucosa and to measure the olfactory evoked potentials (OEP) by electrical stimulation. The illustrative embodiment of the probe, which can be placed in the nasal cavity and can provide appropriate stimulation to the olfactory mucosa, was gradually improved to the spring type, magnet type, and balloon type. The final type became possible to install at the olfactory mucosa area easy and reliably. However, it seemed to be difficult to established as intraoperative monitoring during the study period, because there is a problem that a reproducible OEP waveforms were not detected even if the olfactory mucosa was adequately stimulated.
Free Research Field	脳神経外科学
Academic Significance and Societal Importance of the Research Achievements	この研究の成果として、術中モニタリングとして嗅粘膜を刺激する新たなデバイスを用いたOEPを測定するシステムが構築された。しかし実際の手術において、嗅覚の問題ない症例においても、同様の電極設置、刺激条件で刺激を与え、同じ部位に設置した記録電極から安定したOEPが確実には検出可能ではないことが明らかとなっている。このことは、この研究の基盤となっているヒトにおけるOEPの実用性や意義を見直す必要があることを意味している。