2023 Fiscal Year Final Research Report

Investigation of the efficacy and mechanism of transcranial direct current stimulation for the treatment of acute cerebral infarction.

Research Project

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Project/Area Number	19K09506
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56010:Neurosurgery-related
Research Institution	Osaka University
Principal Investigator	Nakamura Hajime 大阪大学, 大学院医学系研究科, 講師 (80533794)
Co-Investigator(Kenkyū-buntansha)	尾崎友彦大阪大学, 大学院医学系研究科, 特任助教(常勤) (00723123) 貴島晴彦大阪大学, 大学院医学系研究科, 教授 (10332743) 川端修平大阪大学, 大学院医学系研究科, 招へい教員 (20764062) 井筒伸之大阪大学, 医学部附属病院, 医員 (20834170) 西田武生大阪大学, 大学院医学系研究科, 招へい教員 (30533806) 角野喜則大阪大学, 大学院医学系研究科, 招へい教員 (60770675) 高垣匡寿大阪大学, 大学院医学系研究科, 助教 (70724433)
Project Period (FY)	2019-04-01 – 2024-03-31
Keywords	急性期脳梗塞 / 経頭蓋直流電気刺激 / 皮質拡延性抑制
Outline of Final Research Achievements	To investigate the effects of transcranial direct current stimulation (tDCS) on cerebral blood flow during the acute phase of cerebral infarction, we created an experimental system using mouse middle cerebral artery occlusion model and laser speckle flowmetry (LSF). In this experiment, we attempted to visualize hemodynamic change in the presence and absence of tDCS. Unfortunately, we could not prove the effect of tDCS On-Off on blood flow or the inhibition of cortical spreading depression (CSD), however, we observed a gradual increase in cerebral blood flow on the stimulated side regardless of tDCS On-Off in the normal brain and in the peri-infarct area. These results suggest that tDCS may induce a very slow, but not immediate, increase in cerebral blood flow. tDCS may not only have a direct effect on blood vessels, but may also affect other mechanisms of cerebral infarction exacerbation, such as inflammatory responses. We will continue to explore further based on these findings.
Free Research Field	脳血管障害
Academic Significance and Societal Importance of the Research Achievements	本研究では、脳梗塞発症直後にtDCSを行い、その脳表血流を持続的に可視化する手法を確立した。残念ながらtDCSによる劇的な脳血流増加や脳梗塞縮小効果を証明するには至らなかったが、正常脳組織において刺激側の緩徐な血流増加傾向を認めたことは、大きな収穫であったと思われる。今後tDCSは、脳梗塞急性期のみならず超高齢者の慢性脳虚血状態に対する新たな介入方として期待が持てるかもしれない。