The groundwork for the development of new treatments for cerebral aneurysms by establishing cerebral aneurysm model monkeys.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K09524
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Tsuji Keiichi 滋賀医科大学, 医学部, 客員助教 (80838045)
• Co-Investigator(Kenkyū-buntansha): 野崎 和彦 滋賀医科大学, 医学部, 客員教授 (90252452)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: cynomolgus monkey / vascular anatomy / cerebral aneurysm

Outline of Final Research Achievements

In this study, we attempted to create a primate cerebral aneurysm model using female cynomolgus monkeys bred at our institution. In addition, there are few literature reports on cerebral vascular anatomy in primates, and the literature on cerebral vascular anatomy in cynomolgus monkeys could not be confirmed as long as they were hunted.
We clarified the details of the cerebrovascular dissection of cynomolgus monkeys and submitted the results to the journal "Experimental Animals". Regarding the cynomolgus monkey aneurysm model, we plan to submit the research results in the future.

Free Research Field

霊長類脳動脈瘤モデル

Academic Significance and Societal Importance of the Research Achievements

脳動脈瘤の病態解明については、霊長類脳動脈瘤モデルが確立されておらず、げっ歯類脳動脈瘤モデルがその病態解明に主に使用されてきた。今回我々の研究ではカニクイザルの脳動脈構造を明らかにし、モデル動物での動脈瘤形成が確認できた。今後本モデルを用いて更に研究を積み重ねることで、脳動脈瘤の病態解析や新規治療の開発、その安全性や治療効果の確認が可能となり、脳動脈瘤研究の発展が期待できる。