Establishment of animal model of heterotopic ossification and its application to control of ossification

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09570
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Yoshii Toshitaka 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50583754)
• Co-Investigator(Kenkyū-buntansha): 大川 淳 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30251507) ; 湯浅 将人 東京医科歯科大学, 医学部附属病院, 非常勤講師 (80808254) ; 平井 高志 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (40510350)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 異所性骨化

Outline of Final Research Achievements

The main objective of this study is to clarify the pathogenesis of heterotopic ossification. Heterotopic calcification and ossification were observed after muscle injury in ABCC6 mutant mice, which are thought to be the causative gene of Pseudoxanthoma Elasticum. Similarly, heteroopic calcification was observed in plasminogen KO mice, a fibrinolytic enzyme, suggesting that multiple factors with different mechanisms are involved in ectopic ossification. In addition, when ectopic ossification was induced in chondrocyte reporter mice, the ossification mechanism was found to be endochondral ossification.

Free Research Field

整形外科

Academic Significance and Societal Importance of the Research Achievements

異所性石灰化・骨化疾患は骨化性筋炎やアジア人に多い脊柱靱帯骨化症（後縦靱帯骨化症、黄色靱帯骨化症、びまん性特発性骨増殖症など）、延いては動脈硬化などQOLや生命予後に大きく関与する疾患を含んでいる。本研究はその病態に関する新たな知見を見出したことにより、そのいずれかの段階でブロックすることができれば、異所性骨化性疾患の予防薬を創出しうると考える。