Novel biocompatible adhesive for the soft tisuue bonding in orthopedic surgery

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09607
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Keio University
• Principal Investigator: SUZUKI Taku 慶應義塾大学, 医学部(信濃町), 講師 (90445304)
• Co-Investigator(Kenkyū-buntansha): 田口 哲志 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, グループリーダー (70354264)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 生体接着剤

Outline of Final Research Achievements

The purpose of this study was to investigate thebonding strength and biocompatibility of the ApGltn sealant in transected digital nerves of fresh frozen cadavers and in the sciatic nerves of a rat model. Human digital nerves of fresh frozen cadavers were transected for biomechanical traction testing. Sciatic nerves of male Wistar rats were used for functional and histopathologic evaluation.
The maximum failure load of the ApGltn sealant was significantly higher than that of a fibrin sealant (0.22N versus 0.06N). The maximum failure load of the ApGltn sealant was significantly lower that of
suture plus ApGltn sealant (1.37 N) and suture (1.27 N). Functional evaluation and histologic examination showed that sciatic nerves repaired with ApGltn sealant showed similar nerve recovery compared to repair with the suture and fibrin sealant. The ApGltn sealant showed higher bonding strength and equal effect of nerve regeneration when compared with the fibrin sealant.

Free Research Field

末梢神経

Academic Significance and Societal Importance of the Research Achievements

タラゼラチンは, 神経接着において従来のフィブリン製剤と比較して, 高い接着強度を持ち, 組織再生を阻害しないと示された.
本研究の結果から今後タラゼラチンはフィブリン糊に変わって臨床に用いられる可能性が示唆され,新たな医療材料を提供できる可能性が示された. 一方, タラゼラチンのみでは, 従来の縫合には強度が及ばず, 今後のさらなる強度の改良が必要と考えられた.