2021 Fiscal Year Final Research Report
Production of Cell-Containing Hybrid Artificial Bioprostheses for Reproducing Patient-Specific Strength of Articular Cartilage
| Project/Area Number |
19K09658
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Osaka Sangyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
境 慎司 大阪大学, 基礎工学研究科, 教授 (20359938)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 再生医療 / 定量的MR画像 / 3Dバイオプリンタ / プローブ / 軟骨 |
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| Outline of Final Research Achievements |
The objectives of this study were (1) to produce a hybrid artificial bioprosthesis in which a material with adjustable strength is used as a support tissue and filled with biological tissue, and in relation to (1), (2) to explore a method to predict the strength of the tissue using quantitative MR images, and (3) to investigate whether the probe device developed by the principal investigator can predict the strength of the cartilage surface. Unfortunately, we were unable to establish material selection to achieve the objective of (1), but we were able to evaluate the accuracy (i.e. printabilitiy) of the bioprinter, which was a preliminary step. With regard to (2) and (3), we found a correlation between the values on quantitative MR images of cartilage and mechanical properties. In addition, it was found that the mechanical properties could be predicted more accurately by using the above probe device.
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| Free Research Field |
医工学、材料工学、整形外科、
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| Academic Significance and Societal Importance of the Research Achievements |
比較的新しい技術であるバイオプリンタがどんなものか、またどの程度の精度で印刷できるか等、基本的な事柄を、専門外の方々にもわかる手法で表現できたことは大きいと考える。
また、軟部組織の機械特性が定量的MR画像によって、算出できる可能性を見いだせたことも学術的意義があると考える。さらに、この結果が社会実装されれば、どの程度運動をするべきかなど保存的治療の限界も明らかになるだろうし、ひいては日本健康寿命に貢献できると考える。
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