The exploration of urinary biomarkers in patients with interstitial cystitis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09669
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Otsuka Atsushi 浜松医科大学, 医学部, 准教授 (90362201)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 間質性膀胱炎 / 診断 / バイオマーカー / 尿 / 質量分析

Outline of Final Research Achievements

Based on the fact that a non-invasive specific diagnostic method has not been established in the medical care of patients with interstitial cystitis/bladder pain syndrome, the purpose of this study is to identify urinary biomarkers specific to interstitial cystitis/bladder pain syndrome. Urinary samples obtained from patients diagnosed with interstitial cystitis/bladder pain syndrome and healthy adult volunteers were used. We searched urinary biomarkers useful for diagnosing interstitial cystitis/bladder pain syndrome using liquid chromatography-mass spectrometry (LC-MS). As a result, we were able to identify some urinary biomarkers useful for diagnosing interstitial cystitis/bladder pain syndrome. Details of these substance names, etc. cannot be reported at this time because they are being prepared for the application for acquisition of intellectual property rights.

Free Research Field

泌尿器科学

Academic Significance and Societal Importance of the Research Achievements

間質性膀胱炎/膀胱痛症候群は未だ原因不明の慢性進行性疾患であり、その症状により患者の生活の質（QOL）は著しく低下する。また、診断は容易でなく、疾患に精通した泌尿器科医による経験則に基づくことが多い。そのため、間質性膀胱炎/膀胱痛症候群に特異的なバイオマーカーを同定することが急務である。今回我々は、低侵襲に採取可能な尿を用いて、診断に有用なバイオマーカーを数種類同定することができた。これらを用いた診断技術の確立を目指すとともに、今後の診療に用いることができるよう研究を継続する。