Establishment and application development of innovative ablation technology for bladder cancer

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09690
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Okayama University
• Principal Investigator: Edamura Kouhei 岡山大学, 大学病院, 助教 (90535816)
• Co-Investigator(Kenkyū-buntansha): 定平 卓也 岡山大学, 大学病院, 助教 (20733322) ; 那須 保友 岡山大学, 医歯薬学域, 教授 (20237572) ; 和田 耕一郎 島根大学, 学術研究院医学・看護学系, 教授 (20423337) ; 荒木 元朗 岡山大学, 大学病院, 講師 (90467746)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 膀胱癌 / 局所治療 / 薬剤投与法

Outline of Final Research Achievements

To challenge the important issue in the urology field, which is the development of "minimum endoscopic invasive treatment with safe and curative tumor ablation effect that can treat both superficial and invasive bladder cancer". Research methods and strategies were set and research was conducted separately for superficial cancer and invasive cancer. As a result, we were able to obtain certain results on how to administer the drug under cystoscope in order to make the topical treatment of the drug for superficial cancer curative. That is, several types of administered drugs having a tissue ablation effect were analyzed, and findings on the ablation effect on bladder mucosa were obtained.

Free Research Field

泌尿器科

Academic Significance and Societal Importance of the Research Achievements

表在性膀胱癌の治療では経尿道的膀胱腫瘍切除術が第一選択とされる一方、筋層浸潤性膀胱癌については未だ根治性を期待できる内視鏡治療は存在せず、最終的に膀胱全摘除術を余儀なくされる症例も少なくない。本研究では「膀胱癌の内視鏡治療において、アブレーション薬剤を癌病巣局所とその周辺にIn situ permeation systemにより局所投与することにより表在癌と浸潤癌を根治治療することが可能なのか？」といった学術的「問い」を設定し、研究の成果を膀胱癌の内視鏡治療における革新的医療技術の確立へとつなげる方針である。