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2022 Fiscal Year Final Research Report

Intravesical Kv7 channel opener using new drug delivery system

Research Project

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Project/Area Number 19K09710
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56030:Urology-related
Research InstitutionTottori University

Principal Investigator

Honda Masashi  鳥取大学, 医学部, 准教授 (20362890)

Co-Investigator(Kenkyū-buntansha) 武中 篤  鳥取大学, 医学部, 教授 (50368669)
引田 克弥  鳥取大学, 医学部附属病院, 特命准教授 (50403407)
Project Period (FY) 2019-04-01 – 2023-03-31
Keywords下部尿路機能 / 膀胱内圧測定 / 受容体 / 神経ペプチド
Outline of Final Research Achievements

In a series of studies investigating the role of voltage-gated potassium 7 (Kv7) channel openers on lower urinary tract function, we investigated the effects of intravenous administration of ghrelin on the micturition reflex in rats.
Continuous cystometrograms were performed under urethane anesthesia. Ghrelin was administered intravenously to evaluate changes in bladder activity. Intravenous administration of ghrelin increased intercontraction interval. These inhibitory effects of ghrelin were antagonized by intravenous naloxone administration. These results show that ghrelin inhibits the micturition reflex through an opioid-dependent mechanism in rats.

Free Research Field

神経泌尿器科

Academic Significance and Societal Importance of the Research Achievements

本研究課題の成果から、未だにその作用が十分に解明されていないghrelinが正常排尿反射に果たす役割が解明された。神経ペプチドghrelinの経静脈投与は、ラット正常排尿反射をopioidメカニズムを介して抑制する可能性が示唆された。
Ghrelinの経静脈投与による下部尿路機能以外の全身への作用は十分には判明していないものの、本研究成果は過活動膀胱などの下部尿路機能障害に対する新しい薬物療法を確立していく上で、重要な基盤になる知見であると考えている。

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Published: 2024-01-30  

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