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2021 Fiscal Year Final Research Report

Maternal use of pharmaceuticals during pregnancy and congenital malformations in offspring.

Research Project

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Project/Area Number 19K09746
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionFukushima Medical University

Principal Investigator

Nishigori Hidekazu  福島県立医科大学, 公私立大学の部局等, 教授 (40453310)

Co-Investigator(Kenkyū-buntansha) 小原 拓  東北大学, 東北メディカル・メガバンク機構, 准教授 (80612019)
栗山 進一  東北大学, 災害科学国際研究所, 教授 (90361071)
Project Period (FY) 2019-04-01 – 2022-03-31
Keywords妊婦の医薬品使用 / 先天奇形
Outline of Final Research Achievements

We used a large administrative claim database to examine the use of pharmaceuticals by pregnant women and the development of their offspring. The dates of pregnancy onset and delivery were estimated using the developed algorithms. More than 30,000 pregnant women were registered in the administrative claim database. We found no significant association between the major congenital malformations of the offspring and (1) early pregnancy prescriptions of propulsive with domperidone, (2) early pregnancy prescriptions of antihypertensive agents including amlodipine and methyldopa, and (3) early pregnancy prescriptions of calcineurin inhibitors, which are immunosuppressive drugs.

Free Research Field

発達環境医学

Academic Significance and Societal Importance of the Research Achievements

日本の大規模レセプトデータベースを用いて、我々が構築したアルゴリズムにより妊娠期間を推定し、妊婦における医薬品処方と児のmajor congenital malformationとの関連を検討した。妊婦の医薬品使用による先天奇形発症の感受性は、日本人と欧米では異なる可能性が指摘されていることから、本邦独自の検証が大切である。したがって、本研究成果は、本邦独自の妊婦に対する医薬品選択の根拠の創出に向けて、その検証方法も含めて貴重な知見を示した。

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Published: 2023-01-30  

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