Epigenetic changes in neonates born to Japanese mothers with gestational diabetes

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09761
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Keio University
• Principal Investigator: Miyakoshi Kei 慶應義塾大学, 医学部(信濃町), 講師(非常勤) (70265883)
• Co-Investigator(Kenkyū-buntansha): 秦 健一郎 国立研究開発法人国立成育医療研究センター, 周産期病態研究部, 部長 (60360335) ; 河合 智子 国立研究開発法人国立成育医療研究センター, 周産期病態研究部, 室長 (40423404) ; 田嶋 敦 金沢大学, 医学系, 教授 (10396864) ; 荒田 尚子 国立研究開発法人国立成育医療研究センター, 周産期・母性診療センター, 診療部長 (70214723)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 妊娠糖尿病 / 臍帯血メチル化 / エピゲノム変化 / 新生児低血糖 / DOHaD仮説

Outline of Final Research Achievements

Neonates born to mothers with gestational diabetes mellitus (GDM) are at risk of metabolic syndrome in the future. Epigenetic modifications as well as environmental and genetic factors are thought to predispose offspring to develop metabolic disorders, however, data on Japanese subjects are not reported. Our genome-wide methylation analysis demonstrated that neonates in well-controlled GDM may not differ in DNA methylation compared with those born to mothers without GDM. Additionally, changes in DNA methylation might be associated with neonatal plasma glucose 1 hour after birth.

Free Research Field

周産期医学

Academic Significance and Societal Importance of the Research Achievements

本検討により，血糖管理良好なGDM例の臍帯血DNAメチル化は健常例と同等であること，GDM母体からの新生児血糖値は胎児期のメチル化変化に関連することが示唆された．今後，同様のDNAメチル化解析データは児のエピゲノム変化に関する新たな情報となり，Developmental Origin of Health and Disease仮説の解明にも繋がるものと期待される．