The role of lectins in the development of endometriosis.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09802
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Osaka University
• Principal Investigator: Hashimoto Kae 大阪大学, 医学部附属病院, 特任准教授(常勤) (90612078)
• Co-Investigator(Kenkyū-buntansha): 澤田 健二郎 大阪大学, 医学系研究科, 講師 (00452392) ; 小玉 美智子 大阪大学, 医学系研究科, 助教 (70791391) ; 松本 有里 大阪大学, 医学部附属病院, 助教 (90756488)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 子宮内膜症 / レクチン

Outline of Final Research Achievements

The purpose of this study is to investigate the difference of glycan expression in the endometrium of endometriosis and clarify the cause of the endometriosis. First, we planned to perform lectin microarray by fresh tissue samples from surgical specimen. However, we came to conclude that it is more suitable to compare the primary culture cells than tissue. However, there are few cases that have not received hormone therapy, and it has become difficult to obtain samples suitable for primary culture.　Though we modulate the plan to use the formalin-fixed paraffin-embedded sections with laser microdissection. The protein extraction form endometrial epithelial lesion and stromal lesion will be analyze.

Free Research Field

子宮内膜症

Academic Significance and Societal Importance of the Research Achievements

子宮内膜症の発症にかかわる因子が明らかになることで、新しい治療法の開発に役立つ可能性がある。また、子宮内膜症の症状がなくとも子宮内膜症発症を予測できるバイオマーカーを見つけることができれば、早期治療により重症化を防ぐことができる可能性がある。