2021 Fiscal Year Final Research Report

Prevention of hypertensive disorders of pregnancy and improvement of neonatal outcome by Danger Signal suppression

Research Project

PDF

Project/Area Number	19K09829
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Nara Medical University
Principal Investigator	NARUSE Katsuhiko 奈良県立医科大学, 医学部, 講師 (70453165)
Co-Investigator(Kenkyū-buntansha)	常見泰平奈良県立医科大学, 医学部附属病院, 研究員 (20599831) 竹田善紀奈良県立医科大学, 医学部附属病院, 研究員 (50825239) 中野和俊奈良県立医科大学, 医学部附属病院, 研究員 (70805879) 赤坂珠理晃奈良県立医科大学, 医学部, 助教 (90526724)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	妊娠高血圧腎症 / 妊娠高血圧症候群 / Danger Signal / 常位胎盤早期剥離
Outline of Final Research Achievements	A manuscript on inflammatory upregulation and suppression by Danger Signal in adipose tissue by tissue culture written by Juria Akasaka, a member, was published during this period. The principal investigator proved the association between the existing background pathology between different phenotypes of hypertensive disorders of pregnancy and placental abruption using big data during this period. And also Naruse had the opportunity to give an educational lecture at the Japanese Society of Nephrology. On the other hand, progress in basic research has been delayed due to the clinical effort caused by the COVID disaster, and will continue in April 2022 when the representative moves to a new location.
Free Research Field	周産期医学
Academic Significance and Societal Importance of the Research Achievements	妊娠高血圧症候群が妊娠初期の胎盤着床不全に端を発することが明らかとなり、児に対して胎児発育不全や常位胎盤早期剥離といった重篤な異常をもたらす原因として脂肪組織の炎症が関わる可能性を示し、そこにDanger Signalが関与していることが事前の仮説通り証明された。他方、本研究期間では発症予知やハイリスク群の発症予防、児の周産期予後改善につながる方策までは開発することが出来なかった。今後の研究にて証明していくための基礎的な知見を提示することができたと考える。