Therapeutic effects of islets-including amnion transplantation for diabetes

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09839
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Fukuoka University
• Principal Investigator: Sakata Naoaki 福岡大学, 医学部, 准教授 (50431565)
• Co-Investigator(Kenkyū-buntansha): 吉松 軍平 福岡大学, 医学部, 准教授 (50569275) ; 小玉 正太 福岡大学, 医学部, 教授 (90549338)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 膵島移植

Outline of Final Research Achievements

As a promising cellular therapy for diabetes, islet transplantation needs further improvement in the therapeutic outcomes. Amnion is shed light on as a preferable biomaterial for regenerative medicine. We attempted to develop "islet-including amnion", characterized as an amnion containing islets in the inner cavity, and assessed the therapeutic effects by transplanting to diabetic animal models in this study. As a result, we saw some animals with normoglycemia by the transplantation. On the other hand, we also certified the therapeutic effect was not superior to simple islet transplantation. Therefore, further modification might be required for the application of amnion to islet transplantation.

Free Research Field

膵島移植

Academic Significance and Societal Importance of the Research Achievements

羊膜移植は再発翼状片や角膜上皮欠損、角膜穿孔といった難治性の眼疾患に対して施行されているが、本研究は特に再生医療における羊膜利用のさらなる有効性を証明するために企図したものであった。本研究における膵島移植への羊膜利用の成果は十分なものではなかったが、羊膜の幅広い医療応用への可能性を示したと言う点において、本研究には意義があったと考える。