2022 Fiscal Year Final Research Report
Crossroad between Chewing and Drinking: Elucidation of Neural Substrates and Application to Treatment of Dysphagia
Project/Area Number |
19K09849
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56050:Otorhinolaryngology-related
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Research Institution | Yamagata Prefectural Yonezawa University of Nutrition Sciences |
Principal Investigator |
Saitoh Kazuya 山形県立米沢栄養大学, 健康栄養学部, 教授 (20301997)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 嚥下 / アカハライモリ / 三叉神経中脳路核 / 脳機能イメージング |
Outline of Final Research Achievements |
As a critical neural basis for a smooth transition from occlusion/mastication to swallowing, we paid attention to the pathway from the muscle spindles in the masticatory muscles to the hindbrain reticular formation via the trigeminal mesencephalic nucleus.We used the Japanese fire-bellied newt (Cynops pyrrhogaster) as an experimental model because of its easy access to the midbrain. We recorded the optical signals of the midbrain and the hindbrain in response to the electrical stimuli applied to the mandibular nerve with the brain imaging system using endogenous fluorescence from flavor proteins. Although we obtained neural responses from the hindbrain, no optical signal was recorded from the tectum of the midbrain where the trigeminal mesencephalic nucleus exists. A possibility is that the cell density of the trigeminal mesencephalic nucleus was too low in the cynops pyrrhogaster to obtain sufficient fluorescence for the brain imaging.
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Free Research Field |
神経生理学、耳鼻咽喉科学
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Academic Significance and Societal Importance of the Research Achievements |
誤嚥の原因として、咀嚼した食塊を適切なタイミングで咽頭に移送し嚥下運動に移行できない症例がある。従来、このような所見は、咽頭粘膜における感覚受容の低下や嚥下関連筋の収縮力の低下と解釈されることが多かった。本研究では新たに咀嚼運動に伴う体性感覚フィードバックの低下の可能性を提起する。このようなフィードバック情報の伝達過程を明らかにすることで、嚥下障害の新たな病態と、それに対する治療方法の提案が可能になるものと期待される。
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