2022 Fiscal Year Final Research Report
Elucidation of prognostic factors for HPV-associated oropharyngeal carcinoma and prediction of treatment response by liquid biopsy.
Project/Area Number |
19K09883
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56050:Otorhinolaryngology-related
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Research Institution | Hokkaido University |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 頭頸部癌 / 中咽頭癌 / HPV |
Outline of Final Research Achievements |
HPV-associated oropharyngeal carcinomas had a significantly higher rate of Schlafen family member 11 (SLFN11) positivity than non-associated oropharyngeal carcinomas. HPV infection is involved in the high expression of SLFN11 and that SLFN11 is involved in the favorable treatment sensitivity of HPV-associated oropharyngeal carcinoma.
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Free Research Field |
頭頸部癌
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Academic Significance and Societal Importance of the Research Achievements |
HPV感染により発症した中咽頭癌は喫煙、飲酒により発症した中咽頭癌とは臨床病態や分子生物学的特徴が大きく異なる。HPV関連中咽頭癌は非関連癌に比べて予後は良好であるが、一部のHPV関連中咽頭癌においては遠隔転移をきたし予後不良症例も存在する。HPV関連中咽頭癌は本邦のみならず世界的にも発症数は急増傾向にあり、発症や転移機構の解明が待たれるところである。本研究においてHPV関連中咽頭癌とSchlafen family member 11 (SLFN11)遺伝子との関係を明らかにすることができた意義は大きいと思われる。
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