2023 Fiscal Year Final Research Report
Biomarkers of Sinonasal inverted papilloma
Project/Area Number |
19K09894
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56050:Otorhinolaryngology-related
|
Research Institution | University of the Ryukyus |
Principal Investigator |
|
Project Period (FY) |
2019-04-01 – 2024-03-31
|
Keywords | IP / SCCA1 / SCCA2 / 内反性乳頭腫 / 鼻副鼻腔 |
Outline of Final Research Achievements |
We conducted a prospective study to investigate whether preoperative SCCA1 and SCCA2 values could serve as diagnostic markers for Sinonasal Inverted Papilloma (IP) . The study included 102 cases who underwent endoscopic sinus surgery (18 cases of IP, 2 cases of other papillomas, 77 cases of chronic rhinosinusitis (CRS), 4 cases of sinus cancer, and 1 case of vascular tumor). SCCA1 values showed a significant correlation with SCCA2 values (r = 0.510, p < 0.001). ROC analysis for distinguishing IP and other papillomas from CRS yielded an AUC of 0.86 and a Youden index of 1.75. When combined with SCCA2values analysis, the detection system demonstrated a sensitivity of 0.65 and a specificity of 0.98. With a SCCA1 cutoff value of 1.8 ng/ml, SCCA1 and SCCA2 values were suggested to enhance preoperative diagnosis of IP.
|
Free Research Field |
Head and Neck
|
Academic Significance and Societal Importance of the Research Achievements |
鼻副鼻腔内反性乳頭腫(IP)は良性腫瘍であるが,1.正確な術前診断が困難,2.易再発性(手術切除による再発率:10%),3.悪性転化(同時性+異時性:10%)の3つの問題点がある。IPの術前診断は病理検査だが,炎症の合併から術前病理診断率は約50%と低く,悪性病変の合併は見逃されることが多い。治療は内視鏡下切除になるが不十分な場合に再発率は上昇する。術後病理での悪性病変の合併(同時性),経過観察中の悪性化(異時性)は10%に発生し患者生命に関わる。また術後の創部瘢痕は再発病変の早期発見を困難にさせる。本研究でSCCA1、2値の測定がIPの術前診断を強化できると示唆されたことは重要である。
|