Biomarkers of Sinonasal inverted papilloma

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K09894
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: University of the Ryukyus
• Principal Investigator: Yamashita Yukashi 琉球大学, 医学部, 委託非常勤講師 (60569622)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: IP / SCCA1 / SCCA2 / 内反性乳頭腫 / 鼻副鼻腔

Outline of Final Research Achievements

We conducted a prospective study to investigate whether preoperative SCCA1 and SCCA2 values could serve as diagnostic markers for Sinonasal Inverted Papilloma (IP) . The study included 102 cases who underwent endoscopic sinus surgery (18 cases of IP, 2 cases of other papillomas, 77 cases of chronic rhinosinusitis (CRS), 4 cases of sinus cancer, and 1 case of vascular tumor). SCCA1 values showed a significant correlation with SCCA2 values (r = 0.510, p < 0.001). ROC analysis for distinguishing IP and other papillomas from CRS yielded an AUC of 0.86 and a Youden index of 1.75. When combined with SCCA2values analysis, the detection system demonstrated a sensitivity of 0.65 and a specificity of 0.98. With a SCCA1 cutoff value of 1.8 ng/ml, SCCA1 and SCCA2 values were suggested to enhance preoperative diagnosis of IP.

Free Research Field

Head and Neck

Academic Significance and Societal Importance of the Research Achievements

鼻副鼻腔内反性乳頭腫(IP)は良性腫瘍であるが,1.正確な術前診断が困難,2.易再発性（手術切除による再発率：10％）,3.悪性転化（同時性＋異時性：10％）の3つの問題点がある。IPの術前診断は病理検査だが,炎症の合併から術前病理診断率は約50%と低く,悪性病変の合併は見逃されることが多い。治療は内視鏡下切除になるが不十分な場合に再発率は上昇する。術後病理での悪性病変の合併（同時性）,経過観察中の悪性化（異時性）は10％に発生し患者生命に関わる。また術後の創部瘢痕は再発病変の早期発見を困難にさせる。本研究でSCCA1、2値の測定がIPの術前診断を強化できると示唆されたことは重要である。