Elucidation of tryptophan metabolism in eosinophilic sinusitis and development of new therapeutic methods

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K09906
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Ishikawa Ryuji 浜松医科大学, 医学部, 助教 (90436931)
• Co-Investigator(Kenkyū-buntansha): 三澤 清 浜松医科大学, 医学部, 教授 (90334979)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: トリプトファン代謝 / 好酸球性副鼻腔炎 / JESERECスコア / 高速液体クロマトグラフ質量分析計 / インドールアミン酸素

Outline of Final Research Achievements

Although the research was delayed due to research restrictions due to the new corona infection, there was no significant decrease in the number of eosinophilic sinus surgery cases at Hamamatsu University Hospital. Nasal polyp tissue could be collected. The results of plasma tryptophan metabolite analysis showed that tryptophan, 5-hydroxyindoleacetic acid, Kynurenic acid, quinaldic acid, and xanthurenic acid were low in the severe ECRS group. Enzymes such as the enzyme IDO1 were expected to be activated.

Free Research Field

副鼻腔疾患の治療

Academic Significance and Societal Importance of the Research Achievements

血漿トリプトファン代謝物解析の結果は、Triptophanは、コントロール群と比べて重症ECRS群、中等・軽症ECRS群、非ECRS群のすべてでコントロール群が有意に高値を示した。5-Hydroxyindoleacetic acidは、コントロール群と比べて重症ECRS群が有意に低値を示した。同じくKynurenic acidとQuinaldic acidとXanthurenic acidも、コントロール群と比べて重症ECRS群が有意に低値を示した。好酸球副鼻腔炎患者において、トリプトファン代謝異常が症状の増悪に関連していると予想され、今後新規治療ターゲットとなる酵素異常の解析をすすめていく。