2022 Fiscal Year Final Research Report
A research of the effects of adiponectin-related factors on retinal function and morphology.
Project/Area Number |
19K09928
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56060:Ophthalmology-related
|
Research Institution | Hirosaki University (2022) Nagoya University (2019-2021) |
Principal Investigator |
Ueno Shinji 弘前大学, 医学研究科, 教授 (80528670)
|
Project Period (FY) |
2019-04-01 – 2023-03-31
|
Keywords | CTRP9 / AdipoR1 / Retina / Cone cell |
Outline of Final Research Achievements |
Adiponectin receptor-1 (AdipoR1), a receptor for adiponectin, and C1q/TNF-related protein (CTRP) 9, a ligand for AdipoR1, were investigated in knockout mice. AdipoR1 knockout mice showed photoreceptor-derived retinal degeneration. CTRP9 knockout mice showed reduced cone function due to decreased cone number. The decreased cone number was thought to be due to abnormality in the cone development rather than cone degeneration. Since CTRP9 is not expressed in the retina, CTRP9 was suspected to be ectopically released from tissues other than the retina, affecting the number of cone cells in the mouse retina.
|
Free Research Field |
Ophtalmology
|
Academic Significance and Societal Importance of the Research Achievements |
アディポネクチンの受容体のAdiponectin receptor-1 (AdipoR1)のリガンドであり、アディポネクチンの類似物質であるC1q/TNF-related protein (CTRP) 9が網膜の発生において錐体数を調整していることがわかった。CTRP9は網膜に発現していないことから、CTRP9は網膜以外の組織から異所性に放出され、網膜の錐体細胞数に影響を及ぼしていると考えられた。今までに甲状腺ホルモンなどが同様に異所性に錐体の発生に影響を与えていることが報告されているが、CTRP9でも同様の働きがあると考えられ、網膜の錐体発生に関係する重要な因子が発見されたと考えられる。
|