2021 Fiscal Year Final Research Report
Establishment of a new diabetic retinopathy model of mice
| Project/Area Number |
19K09938
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56060:Ophthalmology-related
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 健人 東海大学, 医学部, 准教授 (50235363)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 糖尿病 / 糖尿病網膜症 / 糖尿病網膜症マウス / オートファジー / AMBRA1 |
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| Outline of Final Research Achievements |
We have focused on AMBRA1, a gene found to be essential for the development of the nervous system and known to play an important role in autophagy progression.As the importance of autophagy in diabetes and retinopathy has been reported, it was predicted that autophagy deficiency would exacerbate diabetic retinopathy.We analyzed the effects on diabetic retinopathy using the world's first AMBRA1-conditional knockout (cKO) mice.We found that cKO mice are a model of impaired autophagy and exacerbated inflammation in retina, and that cKO mice induce proliferation of some retinal cells that appear to be retinal progenitor cells, which may alleviate retinal damage due to diabetes.
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| Free Research Field |
糖尿病網膜症とオートファジー
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| Academic Significance and Societal Importance of the Research Achievements |
今回,AMBRA1が,網膜におけるオートファジーや炎症の機序において非常に重要な遺伝子であることが明白になった.さらにはAMBRA1が細胞増殖の制御に重要な因子であることが報告される中.AMBRA1のKOマウスでは網膜前駆細胞と思われる一部の網膜細胞の増殖を誘導し,さらには糖尿病による網膜障害を緩和する可能性を見出した.AMBRA1の制御により,オートファジー,さらには網膜前駆細胞の増殖をコントロールすることが出来れば、新たな糖尿病網膜症治療の開発につながることも期待できる.
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