2021 Fiscal Year Final Research Report
Assessment of functional aqueous humor outflow and prediction of glaucoma treatment effect using anterior segment optical coherence tomography angiography
| Project/Area Number |
19K09968
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56060:Ophthalmology-related
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| Research Institution | Niigata University (2021)
Kyoto University (2019-2020) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
池田 華子 京都大学, 医学研究科, 特定准教授 (20372162)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 緑内障 / OCTアンギオグラフィー / 房水流出主経路 / 治療効果予測 |
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| Outline of Final Research Achievements |
Deep blood flow images by anterior segment OCT angiography (OCTA) reflect the conventional aqueous humor outflow pathway in the superior sclera and intrasclera. There was a significant correlation between deep vessel density and intraocular pressure (IOP) in glaucoma patients. The change over time in the blood flow image in the anterior segment of the eye differed depending on the type of glaucoma instillation, and the effect of reducing IOP by instillation of ripasudil was significantly related to the deep vessel density before instillation. The therapeutic effect of trabecular meshwork-targeted micro-invasive glaucoma surgery was significantly associated with preoperative deep vessel density.
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| Free Research Field |
緑内障
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| Academic Significance and Societal Importance of the Research Achievements |
前眼部OCTAを用いた検査が房水流出主経路の機能評価の参考になりうること、治療前のOCTA画像が一部の緑内障点眼治療や緑内障手術治療の効果と関連することを明らかにした。治療効果に個人差の大きい点眼治療や低侵襲な緑内障手術である流出路再建術の治療効果が治療前に予測可能になれば、患者におけるメリットは大きいと考えられる。
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