New development of burn treatment focusing on cell death

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K10028
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Kyoto University
• Principal Investigator: Matsuura Yoshitaka 京都大学, 医学研究科, 客員研究員 (70772383)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: burn wound progression / apoptosis / silk elastin / wound healing

Outline of Final Research Achievements

In a burn rat model, initial treatment with betamethasone ointment was suggested to prevent burn wound progression. Although histopathological examination confirmed that apoptosis, a type of cell death, was prevalent near the boundary with burn wounds, the relationship between burn wound progression and apoptosis was not clear. We also conducted research using silk elastin sponge as a new treatment for burns. Compared to the control group, the silk elastin group was superior in early epithelialization, granulation formation, and wound healing. Angiogenesis on burn wound was confirmed as one of the mechanisms under use of silk elastin.

Free Research Field

熱傷

Academic Significance and Societal Importance of the Research Achievements

熱傷治療は、創部を早く治癒させることが救命につながるが、熱傷の進行を予防するというう観点も重要である。創傷治癒を早める目的でのシルクエラスチンの使用は有用であり、また、熱傷の進行予防にはステロイドの1種であるベタメタゾン軟膏の初期使用も有用であることが示唆された。