2022 Fiscal Year Annual Research Report
Investigation of chromatic remodeling in osteoclast function for therapeutic targeting of bone remodeling balance
Project/Area Number |
19K10044
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Research Institution | Hokkaido University |
Principal Investigator |
李 智媛 北海道大学, 歯学研究院, 助教 (70711274)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | Osteoclast / Baf155 / Chromatin remodeler / sexual dimorphism |
Outline of Annual Research Achievements |
This study investigated the functional role of Baf155, an epigenetic chromatin remodeler in osteoclasts. In this fiscal year, we found that the effect of Baf155 cKO mice on bone mineral density (BMD) differed between sexes, even at the same age. Interestingly, microCT analysis of 8-week-old mice showed an increase in BMD only in male mice, but there was no difference in BMD at 16 weeks of age. Conversely, in 8-week-old female mice, there was no difference in BMD compared to the control group, but at 16 weeks of age, BMD parameter significantly increased in Baf155 cKO. Our results suggest that the epigenetic regulation of the chromatin regulator Baf155 on osteoclasts and bone differs according to sexual dimorphism.
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Research Products
(5 results)
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[Journal Article] The Lipid-Binding Defective Dynamin 2 mutant in Charcot-Marie-Tooth Disease impairs proper actin bundling and actin organization in Glomerular podocytes2022
Author(s)
2.Hamasaki E, Wakita N, Yasuoka H, Nagaoka H, Morita M, Takashima E, Uchihashi T, Takeda T, Abe T, Lee JW, Iimura T, Saleem MA, Ogo N, Asai A, Narita A, Takei K, Yamada H
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Journal Title
Frontiers in cell and development biology
Volume: 10
Pages: -
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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