Investigation of chromatic remodeling in osteoclast function for therapeutic targeting of bone remodeling balance

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57010:Oral biological science-related
• Research Institution: Hokkaido University (2020-2022); Ehime University (2019)
• Principal Investigator: Lee Ji-Won 北海道大学, 歯学研究院, 助教 (70711274)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: chromatin remodeler / BAF155 / osteoclast / bone

Outline of Final Research Achievements

This study investigated the functional role of Baf155, an epigenetic chromatin remodeler in osteoclasts. In this fiscal year, we found that the effect of Baf155 cKO mice on bone mineral density (BMD) differed between sexes, even at the same age. Interestingly, microCT analysis of 8-week-old mice showed an increase in BMD only in male mice, but there was no difference in BMD at 16 weeks of age. Conversely, in 8-week-old female mice, there was no difference in BMD compared to the control group, but at 16 weeks of age, BMD parameter significantly increased in Baaf155 cKO. Our results suggest that the epigenetic regulation of the chromatin regulator Baf155 on osteoclasts and bone differs according to sexual dimorphism.

Free Research Field

細胞生物-破骨細胞

Academic Significance and Societal Importance of the Research Achievements

Age-related bone resorption diseases are common in women. However, there are no gender-specific clinical trials or drug guidelines. From a gender difference medical perspective, the accumulation of pathophysiological evidence is important.