Analysis of PRMT5 of epithelial-to-mesenchymal transition in oral cancer

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10094
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57020:Oral pathobiological science-related
• Research Institution: Jichi Medical University
• Principal Investigator: Amano Yusuke 自治医科大学, 医学部, 学内准教授 (70571587)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: PRMT5 / 口腔癌 / 上皮間葉移行

Outline of Final Research Achievements

We previously showed that the expression of PRMT5 was associated with EMT in
OSCC specimen. In the present study, I immunohistochemically examined examined associations between the expression of EMT markers and PRMT5 in surgically resected OSCC (n=118). In the YK-4C cases, showing spindle cell pattern, PRMT5 and PRMT1, another arginine methyltransferase, were highly expressed in the nuclei and cytoplasm of the cancer cells. Slug was expressed in the nuclei of the cancer cells. Statistical analyses showed that high expressions of PRMT1 and PRMT5 were significantly associated with high expression of slug. These findings raise the interesting possibility that PRMTs might be regulated in a coordinated manner in aggressive cancer cells that undergo EMT.

Free Research Field

口腔病理学

Academic Significance and Societal Importance of the Research Achievements

PRMT5の口腔癌EMT機構における役割において, Slugとの関連があることが明らかになった. また, 別のPRMTファミリーであるPRMT1も口腔癌EMT機構における役割を担っていることが明らかになった.