Effect of periodontal disease on circulatory system via vascular endothelial function

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10119
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Kanagawa Dental College
• Principal Investigator: Aoyama Norio 神奈川歯科大学, 歯学部, 准教授 (30611024)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 歯周病 / 血管内皮細胞 / 循環器疾患 / 感染 / 炎症 / ペリオドンタルメディシン

Outline of Final Research Achievements

We hypothesized that periodontal disease induces bacterial infection and systemic inflammation, and affects the function of vascular endothelial cells, particularly leading to the onset and progression of vascular disease. The purpose of this study was to compare the conditions of periodontal disease and systemic inflammation in peripheral vascular disease patients and healthy subjects. Healthy subjects and patients with peripheral vascular disease were recruited as subjects for this study at multiple medical institutions. A test of vascular endothelial function and periodontal disease examinations were performed. We found that the group with worsened vascular endothelial function had increased tooth mobility.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

歯周病と循環器疾患の関連が知られているが、歯周病治療によって循環器疾患が抑制できるかについてはわかっていない。そこで我々は血管内皮細胞に着目し、歯周病との関連を調査した。歯周病と循環器疾患とが関連する理由がわかれば、治療のターゲットとして制御することにより、歯周病の管理が最終的に循環器疾患予防につながる可能性があり、多くの循環器疾患患者および生活習慣病を有する予備軍の人たちの健康に対して、大きな利益が得られる。