2022 Fiscal Year Final Research Report
Impact of blood glucose control on periodontal regenerative therapy and implant treatment.
Project/Area Number |
19K10125
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 57030:Conservative dentistry-related
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Mizutani Koji 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (60451910)
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Co-Investigator(Kenkyū-buntansha) |
上野 剛史 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (30359674)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 歯周病 / 糖尿病 / 酸化ストレス / インスリン抵抗性 |
Outline of Final Research Achievements |
In this study, we investigated the mechanism by which hyperglycemia inhibits Akt activation of the insulin signaling pathway in vitro using gingival fibroblasts and bone marrow-derived stem cells. Based on the results of the in vitro experiments, it was shown that hyperglycemia and its glycemic control in diabetic animal models are involved in the improvement of gingival wound healing, healing after periodontal tissue regeneration therapy, and osseointegration of implants. The results of this study may contribute to the establishment of safe and predictable dental treatment for diabetic patients.
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Free Research Field |
歯周病
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Academic Significance and Societal Importance of the Research Achievements |
現在、糖尿病はわが国において増加傾向にあることが指摘されており、糖尿病患者の歯周炎は進行しやすいことから、今後、歯科医療の現場において糖尿病患者に対する歯周組織再生療法、およびインプラント治療の安全性や予知性を高めることは喫緊の課題と考えられる。本研究で得られた知見が内科および歯科の臨床現場に与える意義は大きいと考えられる。
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