Malnutrition delayed wound healing by HMGB1-related prolonged inflammation

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10128
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Kobe Tokiwa Junior College (2021); Okayama University (2019-2020)
• Principal Investigator: Yamashiro Keisuke 神戸常盤大学短期大学部, 口腔保健学科, 教授 (30581087)
• Co-Investigator(Kenkyū-buntansha): 青柳 浩明 岡山大学, 歯学部, 客員研究員 (10814501) ; 宝田 剛志 岡山大学, 医歯薬学総合研究科, 教授 (30377428) ; 西堀 正洋 岡山大学, 医歯薬学総合研究科, 特命教授 (50135943)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 歯周病 / 炎症 / 低栄養 / 創傷治癒 / HMGB1

Outline of Final Research Achievements

In Japan, the gap between average life expectancy and healty life expectancy bacomes a big problem. This divergence is caused by diseases such as fractures and lifestyle-related diseases in the elderly. Malnutrition is one of the causes of further exacerbation of these diseases. In this study, we hypothesized that HMGB1, an inflammation mediator, is involved as one of the causes of prolonged inflammation during malnutrition. We made the malnutrition model mice and observed the wound healing process after tooth extraction. The factors related to inflammation (HMGB1 and IL-1β) expression were increasedand the actores related to regeneration and mesenchymal stem cells were decreased in the malnutriotion group compared to the control group. From these results, it was clarified that HMGB1-mediated delayed wound healing occurs in malnutrition.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

高齢者の低栄養はQOL向上の点からも大変重要な課題である。低栄養になると，傷が治癒しにくくなったり，すでに抱えている慢性疾患が悪化したりすることが考えられる。我々はHMGB1という因子が炎症を悪化させるだけでなく，傷が治る際にも重要な働きをすることを明らかとしてきた。本研究において，低栄養時のHMGB1の働きの一部が解明された。今後はHMGB1を検査に用いたり，また低栄養の患者に対して適切な栄養補助を行う際の指標になりうると考えられる。