Development of a potential new marker of periodontal disease status based on serum IL-1 receptor accessory protein .

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10135
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: The Lion Foundation for Dental Health
• Principal Investigator: Ishihara Yuichi 公益財団法人ライオン歯科衛生研究所(研究部研究開発室), 研究部研究開発室, 研究開発室長 (50261011)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 歯周病 / IL-1 / sIL-1RAcP / 血清マーカー

Outline of Final Research Achievements

Interleukin-1 (IL-1), which acts directly on local inflammatory bone resorption, is closely involved in the development and progression of periodontal disease. IL-1 is detected at high levels in periodontal tissues and gingival crevicular fluid from patients with periodontitis, but is almost undetectable in peripheral blood serum. On the other hand, serum IL-1 receptor accessory protein (sIL-1RAcP) was reported to be detectable in the serum of healthy subjects. Therefore, we statistically analyzed the relationship between IL-1RAcP concentration in periodontal patient serum and periodontal pathology, and found that sIL-1RAcP concentration was significantly higher in periodontal patients than in healthy subjects, and decreased to the same level as that in healthy subjects in maintenant patients.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

国民病ともいえる歯周病は、歯科医による詳細な口の検査とエックス線を利用しなければ歯周炎の程度がわからないのが現状である。そこで肝臓で作られ、血液中に存在するインターロイキン-1受容体補助タンパク質濃度に着目し、歯周病を有する人ではその濃度が高く、有しない人や歯周病がコントロールされている人では濃度が低いことが明らかとなった。したがって、このタンパク質を健康診断で測定できれば、歯周病の発症の有無とその程度を簡単に把握できるようになる可能性が示唆された。