2023 Fiscal Year Final Research Report
Development of biologically active direct pulp capping and dentin-pulp complex regeneration inducing agents with highly water containing hydrous gelatinous
| Project/Area Number |
19K10156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | Aichi Gakuin University (2021-2023)
Kyushu Dental College (2019-2020) |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 象牙質・歯髄複合体 / 直接覆髄 / bioactive glass / 根管洗浄 |
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| Outline of Final Research Achievements |
Dental pulp concervative management is important for the maintenance of tooth function as well as for the preservation of the tooth itself. However, pulp is a poorly compliant tissue, it is important to establish pulp concervative/regeneration therapy.The purpose of this study was to develop new agents and materials based on those already in clinical use to achieve pulp preservation and localized dentin-pulp complex regeneration that can be performed using existing instruments, equipment, and techniques.
Using hyaluronic acid, which has been shown to be useful as a scaffold material for dentin-pulp complex regeneration, as the base material, and by mixing FGF-2-impregnated gelatin sponge and bioactive glass particles, the potential for a new agent with bone tissue induction properties was demonstrated. We also confirmed the possibility of a new mildly-ittirating and highly bactericidal root canal and pulp cleaning method, which is necessary to perform the procedure.
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| Free Research Field |
歯科保存学
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| Academic Significance and Societal Importance of the Research Achievements |
歯髄は歯の知覚、栄養、免疫応答、そして修復といった健全な歯の機能維持に重要な役割を果たす組織である。一方で、歯髄は象牙質・エナメル質といった歯の硬組織に周囲を囲まれた特殊な環境下に存在するため、周囲組織との交通が限定されるうえ炎症時に体積の増加が不可能であり内圧亢進により循環障害に陥りやすく、その結果、壊死に至りやすい。
歯髄の有無は歯の寿命にも大きく影響することが知られており、残存歯数は人々のＱＯＬの向上のみならず、健康寿命とも相関することが示されている。そのため、現在では歯髄保存が困難とされる中等度以上の炎症状態に陥った歯髄を保存可能にすることは、健康寿命の延長に大変有用である。
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