2021 Fiscal Year Final Research Report
Observation of cell movement after the implantation of mouse incisal apical bud cells to molars
| Project/Area Number |
19K10162
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
Sakagami Ryuji 福岡歯科大学, 口腔歯学部, 教授 (50215612)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | apical bud / セメント質 / Hertwig上皮鞘 / Malassezの上皮遺残 / 上皮間葉転換 |
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| Outline of Final Research Achievements |
The anterior teeth of rodents such as mice continue to grow throughout their lives, due to the presence of tissue stem cells at the apex of the anterior teeth. We collected this from GFP mice under a microscope, transplanted it into wild-type mice, and observed it for up to 6 months. As a result, it was revealed that these tissue stem cells shows epithelial-mesenchymal transformation and differentiate into cementoblasts that play a role in connecting the teeth and surrounding tissues. By applying this mechanism of cell differentiation, it could be applied to the regeneration of teeth and the regeneration of tissues lost due to periodontal disease.
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| Free Research Field |
歯周病学分野
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| Academic Significance and Societal Importance of the Research Achievements |
抜け落ちた歯の再生、歯周病によって失われた歯周組織の再生は、再生療法における次の大きなターゲットである。歯はセメント質と歯根膜を介して、周囲の歯槽骨とつながっている。セメント質を形成するセメント芽細胞の由来については、これまで間葉系細胞由来であると一般的に考えられてきた。われわれの研究によって、組織幹細胞が移植後に上皮間葉転換を生じてセメント芽細胞となることを初めて検証できた。このメカニズムを応用することで、今後の再生医療の展開につながる可能性がある。
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