2022 Fiscal Year Final Research Report
Biomarker for thr evaluation of nociplastic pain due to the central sensitization
Project/Area Number |
19K10204
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 57050:Prosthodontics-related
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Research Institution | Osaka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
矢谷 博文 大阪大学, 大学院歯学研究科, 招へい教員 (80174530)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 慢性疼痛 / 中枢性感作 / 顎関節症 |
Outline of Final Research Achievements |
Temporal summation of second pain (TSSP) has been suggested as a psychophysical index for central sensitization. However, there is no gold standard for protocols to measure TSSP. The purpose was to establish the stimulus intensity for measuring TSSP. Female with chronic myofascial TMD pain (n=16) and healthy female volunteers (n=15) participated. Pain thresholds (PT °C) were measured, and repetitive heat stimuli at three stimulus intensities (PT, PT+1, and PT+2 °C) were applied. TSSP parameters were quantified as TSSP magnitude (TSm) and TSSP frequency (TSf). Healthy volunteers and chronic pain patients showed different pain ratings. At PT+2, TSm and TSf in chronic pain patients were significantly higher than those in healthy volunteers (p<0.050). It could be helpful to measure TSSP with the stimulus intensity adjusted individually to the patient’s pain thresholds plus 2 °C for assessing central sensitization.
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Free Research Field |
歯科補綴学,口腔顔面痛学
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Academic Significance and Societal Importance of the Research Achievements |
慢性疼痛患者においてしばしば認める組織損傷に不釣り合いな痛みの訴えなどの神経生物学的に説明することができなかった症状は,中枢性感作の結果であると理解されており,慢性疼痛において重要な概念である.本研究は,患者の疼痛閾値に合わせて刺激強度を個別に調整したtemporal summation of second painの臨床的同定を検討した初めての研究である.本研究結果により,temporal summation of second painを測定するための刺激強度を設定する臨床パラダイムのエビデンスが得られ,慢性疼痛患者の診断に有益な情報を提供できたものと考えている.
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