2022 Fiscal Year Final Research Report
Can metformin prevent alveolar bone resorption?
| Project/Area Number |
19K10232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Asahi University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | メトホルミン / 加齢 / 骨吸収 / 歯周病 / 歯肉 / 局所投与 |
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| Outline of Final Research Achievements |
Previous studies have demonstrated the efficacy of topically administered metformin in the gingiva for inflammatory bone resorption and periodontal treatment. However, there have been no attempts to prevent the onset or progression of periodontitis with metformin. In this study, we aimed to clarify whether topical metformin administration to the gingiva is effective in preventing alveolar bone resorption.
It was suggested that topical metformin administration in the gingival tissues may also suppress the underlying inflammation caused by aging. Topical metformin administration suppressed inflammation and bone resorption during the development of experimental periodontitis in aged mice, and also reduced the number of TRAP-positive cells. These results suggest that topical metformin administration to the gingiva may be effective in preventing the onset of periodontitis.
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| Free Research Field |
歯周病学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は, 薬剤による顎堤吸収予防の基礎的な知見となる. メトホルミンの有効性が明らかになれば, メインテナンス来院時に, 顎堤保全のため薬剤を予防投与するという制御医療のあり方を社会に提示できる.
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