2021 Fiscal Year Final Research Report
Bone marrow microenvironment of MRONJ and application of Escherichia coli derived BMP-2
Project/Area Number |
19K10246
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 57050:Prosthodontics-related
|
Research Institution | Okayama University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
窪木 拓男 岡山大学, 医歯薬学域, 教授 (00225195)
大野 彩 (木村彩) 岡山大学, 大学病院, 講師 (20584626)
大野 充昭 岡山大学, 医歯薬学域, 准教授 (60613156)
秋山 謙太郎 岡山大学, 大学病院, 講師 (70423291)
|
Project Period (FY) |
2019-04-01 – 2022-03-31
|
Keywords | MRONJ / BMP-2 |
Outline of Final Research Achievements |
The pathogenesis of medication - related osteonecrosis of the jaws (MRONJ) remains largely unknown. Therefore, it is essential to elucidate the pathogenesis of MRONJ and to develop a treatment for this disease. We hypothesized that BMP-2, which has strong osteogenic potential, might be useful in the treatment of MRONJ. In fact, a mouse MRONJ model was created and rhBMP-2 was administered into the extraction socket. The results showed that bone formation in the extraction socket was suppressed in the non-transplanted group, whereas bone formation was significantly enhanced by rhBMP-2 transplantation. These results suggest that BMP-2 may be a new treatment for MRONJ.
|
Free Research Field |
歯科補綴学
|
Academic Significance and Societal Importance of the Research Achievements |
近年,骨吸収抑制薬の使用による大腿骨非定型骨折や外耳道骨壊死が報告され,骨吸収抑制薬は顎骨だけではなく全身の骨への影響が示唆されている.本研究で得られるMRONJ発症の理解および治療法の開発は,顎骨以外の全身の骨組織への影響の理解にもつながることは言うまでもなく,骨粗鬆症や大理石骨病などの全身性骨代謝性疾患の治療に十分応用が可能である.したがって,本申請研究による成果は歯科分野に留まることなく,医療分野全体へ広く貢献することは明らかである.
|