The efficacy of an oral appliance on nocturnal blood pressure surges in obstructive sleep apnea.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10255
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Osaka Dental University
• Principal Investigator: OKUNO Kentaro 大阪歯科大学, 歯学部, 講師 (50420451)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 歯科 / 睡眠時無呼吸 / 口腔内装置 / 高血圧 / 睡眠障害

Outline of Final Research Achievements

A crossover study was conducted in 22 OSA patients with pre-existing hypertension, randomly assigned to OA treatment group or placebo group. 22 patients had a significant reduction in REI of 22.8 vs. 10.0/h (p<0.01) in the OA group. In terms of PTT blood pressure, mean systolic blood pressure during wakefulness was 131.7 vs. 121.4 mmHg (p<0.01), and mean systolic blood pressure during sleep was 123.3 vs. 112.8 mmHg (p<0.01), a significant decrease in the OA group, suggesting that OA treatment may be effective in treating nocturnal blood pressure surges.

Free Research Field

睡眠時無呼吸

Academic Significance and Societal Importance of the Research Achievements

本研究結果から、歯科で行う閉塞性睡眠時無呼吸(OSA)に対する口腔内装置(OA)治療は、高血圧を合併しているOSA患者の、夜間の血圧サージに対しても有効である可能性が示唆された。本研究により、口腔内装置治療は、いびきや日中の眠気などの患者のQOLに関わる症状の改善だけではなく、心血管疾患・脳血管疾患の進行や心臓突然死のリスクを下げるなど生命予後に対しても効果が期待できると考えている。