2021 Fiscal Year Final Research Report

Establishment of a new photodynamic diagnostic method focusing on abnormal porphyrin metabolism in oral cancer cells and trial for clinical application

Research Project

PDF

Project/Area Number	19K10276
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 57060:Surgical dentistry-related
Research Institution	Tsurumi University
Principal Investigator	Shimozuma Masashi 鶴見大学, 歯学部, 非常勤講師 (50612008)
Co-Investigator(Kenkyū-buntansha)	徳山麗子鶴見大学, 歯学部, 学内講師 (20380090) 井出信次鶴見大学, 歯学部, 助教 (00611998) 里村一人鶴見大学, 歯学部, 教授 (80243715) 寺田知加鶴見大学, 歯学部, 助教 (40460216) 舘原誠晃鶴見大学, 歯学部, 講師 (90380089)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	蛍光診断 / 口腔癌 / 上皮性異形成 / 5ALA
Outline of Final Research Achievements	Early detection of oral cancer is important for improving prognosis and maintaining quality of life after treatment. It is desired to develop a new diagnostic device capable of accurately and highly sensitively visualizing minute lesions that are difficult to detect by inspection. In this study, we focused on abnormal porphyrin metabolism occurring in cancer cells and aimed to establish a new photodynamic diagnostic method for oral cancer applying 5-aminolevulinic acid (ALA-PDD). As a result, the result of fluorescence diagnosis by ALA-PDD was in agreement with the result of histopathological diagnosis. This photodynamic diagnostic method was able to clearly distinguish between lesions that require or are recommended for resection, namely SCC, CIS, severe dysplasia and moderate dysplasia lesions, and follow-up mild dysplasia lesions.
Free Research Field	再生医療、口腔外科全般、口腔内科全般
Academic Significance and Societal Importance of the Research Achievements	近い将来、口腔癌患者の増加・高齢化に伴い、口腔癌治療の副作用や術後の機能障害によるQOLの著しい低下が大きな問題となることが予想される。すでにこの問題は起こりつつあり、臨床現場ではいかに患者のQOLを維持出来る治療法を選択するかということに苦慮している。ALA-PDDの潜在的有用性は極めて高く、この診断技術を多くの医療施設に適切に普及させることができれば、口腔癌の早期発見を基盤とした低侵襲治療の実現、国民のQOLの維持・向上、および生命予後の向上を図ることができるとともに、わが国の医療経済の悪化抑制にも資するものと考えられる。