2021 Fiscal Year Final Research Report

Standardization of SPECT quantitative analysis for osteomyelitis of the jaw and challenges for the development of treatment method of ARONJ

Research Project

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Project/Area Number	19K10279
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 57060:Surgical dentistry-related
Research Institution	Hokkaido Cancer Center(Department of Clinical Research)
Principal Investigator	Hata Hironobu 独立行政法人国立病院機構北海道がんセンター(臨床研究部), 臨床研究部, 歯科口腔外科医師 (70450830)
Co-Investigator(Kenkyū-buntansha)	北川善政北海道大学, 歯学研究院, 教授 (00224957) 大賀則孝北海道大学, 歯学研究院, 助教 (40548202) 今待賢治独立行政法人国立病院機構北海道がんセンター(臨床研究部), 臨床研究部, 歯科口腔外科医師 (40779873) 佐藤淳北海道大学, 歯学研究院, 准教授 (60319069) 齊田友香 (北尾友香) 北海道大学, 医学研究院, 客員研究員 (60838142) 浅香卓哉北海道大学, 歯学研究院, 助教 (80637265)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	定量SPECT / 骨シンチグラフィ / 骨吸収抑制剤関連顎骨壊死顎骨壊死 / MRONJ
Outline of Final Research Achievements	In this study, quantitative image analysis of bone SPECT was performed before and after medication related osteonecrosis of the jaw (MRONJ)'s anti-inflammatory treatment. As a result, we demonstrated that standardized uptake value(SUV) comparison and monitoring between patients in the same facility is possible. In addition, bone SPECT quantitative analysis proved to be a highly reproducible test method. When 14 new cases of SPECT imaging for dental osteomyelitis that did not use BP were added and compared, the SUV value of the parietal bone was higher than that of BP used cases MRONJ. It was found that dental osteomyelitis was significantly lower (p <0.01), and that there was a correlation between the duration of BP use and the SUV value of the parietal bone.These results were published in two English articles.
Free Research Field	口腔画像診断
Academic Significance and Societal Importance of the Research Achievements	骨SPECT定量解析ソフトウェアを骨髄炎の活動性ならびに治療効果のモニタリングに応用することを実現した本研究の成果は、実臨床のおいて非常に有益である。本研究結果はMRONJと併存する顎骨骨髄炎の重症度を正確に捉えたものであり、MRONJの治療・予防という社会貢献に繋がる可能性を秘めている