Role of Caveolin-1 and IL-6 for oral cancer

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10338
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Yokohama City University
• Principal Investigator: MITSUDO Kenji 横浜市立大学, 医学研究科, 教授 (70303641)
• Co-Investigator(Kenkyū-buntansha): 梅村 将就 横浜市立大学, 医学部, 准教授 (50595353)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 口腔癌 / Caveolin-1 / IL-6 / シグナル伝達

Outline of Final Research Achievements

We generated Cav-1 knockdown cells and observed the proliferation, metastasis and migration of oral cancer cells upon IL-6 stimulation. As a result, Cav-1 knockdown inhibited the growth-promoting function of IL-6. Studies on metastasis/migration did not show clear results regarding metastasis/migration of Cav-1, suggesting the possibility that there is no relationship between Cav-1 and cancer metastasis/migration.
From these results, regarding the relationship between Cav-1 and IL-6, although both Cav-1 and IL-6 play important roles in cancer growth, there is no direct effect of both. became. In the future, it is necessary to investigate the mechanisms by which they act separately.

Free Research Field

口腔癌

Academic Significance and Societal Importance of the Research Achievements

口腔癌におけるCav-1の存在下および非存在下でのIL-6誘発性シグナル伝達の影響について検討を行った結果、癌の増殖にCav-1とIL-6双方が重要な役割を果たすものの，両者の直接的な作用は見られないことが明らかになった．この結果は、多面的要因の影響を受ける癌の増殖において、Cav-1とIL-6は独自のシグナルを介して影響を及ぼしていることを明らかにした。本研究は今後Cav-1やIL-6の機能調節を行うキーシグナルを明らかにし，治療ターゲットを見出すきっかけとなる研究であったと考える。