Effect of peripheral sensory input on swallowing reflex evoked by esophageal stimulation

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10428
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57080:Social dentistry-related
• Research Institution: Asahi University
• Principal Investigator: TANIGUCHI HIROSHIGE 朝日大学, 歯学部, 准教授 (80529636)
• Co-Investigator(Kenkyū-buntansha): 青柳 陽一郎 日本医科大学, 大学院医学研究科, 大学院教授 (30286661)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 嚥下反射 / 食道刺激 / 摂食嚥下障害

Outline of Final Research Achievements

Based on a physiological research approach, this study aimed to clarify the following: 1) Effects of different peripheral stimulation and the posture of subject on swallowing movement, 2) Effects of aging and diseases on swallowing movement caused by esophageal stimulation.
In the first year, the effects of the test food temperature and the posture of subject on swallowing movement were examined, and in the second year, the effects of different chemical stimulation on the induction of the swallowing reflex were examined. In the final year, this method was applied to dysphagia patients who had a history of cerebrovascular accidents. The results of this study clarified the conditions under which the swallowing reflex was induced more efficiently by esophageal stimulation, and suggested that esophageal stimulation induces the swallowing reflex even on dysphagia patients.

Free Research Field

摂食嚥下リハビリテーション学

Academic Significance and Societal Importance of the Research Achievements

摂食嚥下障害の臨床においては，基礎データが構築されないまま，臨床的な経験値のみで実施されているものが多い。本研究によって，健常者における咽頭・食道内圧値が算出され，食道刺激と嚥下反射との定量的評価が明らかとなった。
結果によって摂食嚥下の障害解明や治療法確立の新たな手がかりを導くことが期待できる。本研究の手法が確立すれば，歯科領域のみならず摂食嚥下に関わる医科領域においても新たな訓練法の確立，障害の解明に有効なデータ収集が可能となる。