2021 Fiscal Year Final Research Report
Long-term prognosis analyzed by the effect of diabetic kidney disease phenotypes and the effect of secular trends in type 2 diabetes
| Project/Area Number |
19K10483
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58010:Medical management and medical sociology-related
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
荒木 信一 滋賀医科大学, 医学部, 非常勤講師 (80378455)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 糖尿病 / 臨床疫学 / 生命予後 / 心血管疾患発症率 / コホート研究 |
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| Outline of Final Research Achievements |
Cohort studies performed in Japan Diabetes Data Management study group (JDDM) revealed that the risk of death, cardiovascular disease morbidity and renal function decline was not poor in patients with decreased renal function if albuminuria remained normal.
Trend analysis in diabetes therapy and HbA1c from 2002 to 2018 showed that HbA1c continued to improve until 2014 and remained unchanged thereafter in Japanese patients with type 2 diabetes, irrespective of the treatment modality.
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| Free Research Field |
糖尿病
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| Academic Significance and Societal Importance of the Research Achievements |
腎機能低下があれば正常アルブミン尿であっても糖尿病者の死亡と心血管疾患発症は増悪することが欧米の研究で述べられている。日本人では心血管疾患既往者が少なく管理も良いことが今回研究結果と欧米との差異へ影響していると考えられる。他方で糖尿病者の高齢化と低血糖リスク軽減を考慮した管理基準の緩和化が、HbA1cの推移として平坦化として最近表れて来ており、今回の研究成果は、今後これらを含めた至適対策への基盤になると考えられる。
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