Investigation of neurodevelopmental risks in children associated with pesticide exposure: Using genetic polymorphisms (SNPs) analysis.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10576
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Hokkaido University
• Principal Investigator: Nishihara Shinkichi 北海道大学, 環境健康科学研究教育センター, 客員研究員 (10584344)
• Co-Investigator(Kenkyū-buntansha): 池田 敦子 北海道大学, 保健科学研究院, 教授 (00619885) ; 小林 澄貴 北海道大学, 環境健康科学研究教育センター, 特任准教授 (10733371)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ネオニコチノイド系農薬 / 有機リン系農薬 / 曝露濃度 / ADHD

Outline of Final Research Achievements

Measuring metabolites of neonicotinoid and organophosphorus pesticides in urine samples from school-age children, this study examined the association between exposure to these pesticides and children's ADHD scores. As a result, no significant associations were observed for neonicotinoid pesticides or for organophosphorus pesticides.This suggests that exposure to these pesticides is not associated with an increase in ADHD tendency in children if the concentrations are at levels that children in the general urban population can be exposed to in their normal daily lives. However, interpretation may need to be done with caution for imidacloprid, one of the neonicotinoid pesticides, because the odds ratio tends to increase, although the difference has not reached significance.

Free Research Field

環境疫学

Academic Significance and Societal Importance of the Research Achievements

都市部の一般集団を用いて、子どものネオニコチノイド系農薬、および、有機リン系農薬への曝露と神経発達との関連を検討した研究は世界的に少なく、特にネオニコチノイド系農薬との関連についてバイオマーカーを用いて検討した研究は全く存在しない。したがって、本研究で得られた成果は、農薬の毒性を評価するという観点に立脚した場合、日本のみならず世界においても極めて重要なものと位置づけられる。