2022 Fiscal Year Final Research Report
To clarify the risk of hepatotoxicity after chronic inhalation exposure to 2-ethyl-1-hexanol in mice
| Project/Area Number |
19K10578
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 2-エチル-1-ヘキサノール |
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| Outline of Final Research Achievements |
2-Ethyl-1-hexanol (2EH) is a volatile organic compound that causes sick building syndrome.It is of interest as a volatile organic compound that causes Sick Building Syndrome and, when administered orally, exhibits peroxisome proliferator-activated receptor (PPAR)α-mediated hepatotoxicity. In this study, we evaluated the toxicological changes in mouse liver after 3-month (subchronic study) and 6-month (chronic study) inhalation exposure.
Although relative liver weights increased in a dose-dependent manner in both studies, they did not meet the criteria for being considered toxic effects. Furthermore, the 2EH inhalation exposure concentrations in this study appeared to have only limited effects on PPARα-related signaling.
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| Free Research Field |
環境化学物質による健康リスク
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| Academic Significance and Societal Importance of the Research Achievements |
2-エチル-1-ヘキサノール（2EH）は、シックビル症候群を引き起こす揮発性有機化合物として注目されている。2EH は、フタル酸ジ（2-エチルヘキシル）（DEHP）の加水分解により発生し、竣工後10 年以上経過した建物において高濃度検出される事例が報告されている。本研究は２EHのマウスへの吸入曝露は、毒性影響とされる基準を満たさないことが示唆され、ペルオキシゾーム増殖剤活性化受容体(PPAR)α関連シグナルには限定的な影響しか及ぼさないことを見出した。2EH の室内濃度指針値の設定には、肝毒性のみならず、他の毒性学的エンドポイントに基づいて設定する必要性を示した。
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