2021 Fiscal Year Research-status Report
A Cross-sectional Study on Invasive Bacterial Infections Associated with Severe Malaria Among Children Hospitalized in Western Kenya
| Project/Area Number |
19K10601
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| Research Institution | Nagasaki University |
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Principal Investigator |
モハマド シャー 長崎大学, 熱帯医学研究所, 助教 (40648086)
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| Co-Investigator(Kenkyū-buntansha) |
金子 聰 長崎大学, 熱帯医学研究所, 教授 (00342907)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | Septicemia / Malaria / Hospitalized children / Western Kenya |
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| Outline of Annual Research Achievements |
Invasive bacterial infections are common causes of bacterial septicemia in African children. This research aims to investigate the prevalence of invasive bacterial infections in children under five years of age hospitalized in rural and urban areas of Western Kenya and examine their pathogenicity, clinical symptom, antimicrobial susceptibility, and the relationship with Malaria severity. We collected blood samples from 82 hospitalized children with septicemia symptoms in Western Kenya. We isolated bacteremia causing pathogenic bacteria such as S. pneumoniae, S. aureus, S. epidermidis, Klebsiella, Salmonella spp, etc. Also, 40% were co-infected with malaria. Currently, sample collection is ongoing. This study will contribute to determining the common causes of childhood mortality and morbidity in Western Kenya and may benefit to develop public health interventions to control the infection.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
Sample collection was delayed due to the COVID-19 pandemic.
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| Strategy for Future Research Activity |
Currently, we are collecting blood samples from hospitalized children under five years old from HomaBay County Referral hospital and Mbita sub-county hospital. For research purposes, all blood samples are transferred to the Nagasaki University Research lab in Mbita. We store all patients' clinical and epidemiological data and perform laboratory tests such as malaria, antimicrobial, biochemical, and molecular tests. We will continue all procedures until February 2023.
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| Causes of Carryover |
Sample collection was delayed due to the COVID-19 pandemic. However, the remaining budget will be used to purchase reagents like malaria kits, AST kits, biochemical and molecular test kits, and plastic consumables.
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