2022 Fiscal Year Annual Research Report
A Cross-sectional Study on Invasive Bacterial Infections Associated with Severe Malaria Among Children Hospitalized in Western Kenya
| Project/Area Number |
19K10601
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| Research Institution | Nagasaki University |
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Principal Investigator |
モハマド シャー 長崎大学, 熱帯医学研究所, 助教 (40648086)
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| Co-Investigator(Kenkyū-buntansha) |
金子 聰 長崎大学, 熱帯医学研究所, 教授 (00342907)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | Bacteremia / Malaria / Hospitalized children / Western Kenya |
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| Outline of Annual Research Achievements |
Invasive bacterial infections are common causes of bacterial bacteremia in African children. This research aims to investigate the prevalence of invasive bacterial infections in children under five years of age hospitalized in rural and urban areas of Western Kenya and examine their pathogenicity, clinical symptoms, antimicrobial susceptibility, and relationship with Malaria severity. Blood samples were collected from 126 hospitalized children with bacteremia symptoms in Western Kenya. This study shows that bacteremia is the leading cause of febrile illness, and Streptococcus pneumoniae is the common etiological agent causing bacteremia. Our results demonstrate that 32.3% and 24.1% of patients were co-infected with malaria in urban and rural areas, respectively. Antibiotic resistance pattern showed that Ampicillin, Nitofurantoin, Streptomycin, Nalidixic acid, and Co-Trimoxazole are commonly resistant to bacteremia-causing pathogens. A positive association of bacteremia in children was found with age, BMI, vomiting, household person, and drinking tap water groups. This study will contribute to determining the common causes of childhood mortality and morbidity in western Kenya and may benefit the development of public health interventions to control infection. Currently manuscript is under preparation.
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