2022 Fiscal Year Final Research Report
Antimicrobial resistance and molecular epidemiological characterization of nonencapsulated Streptococcus pneumoniae after the introduction of pneumococcal conjugate vaccine in Japan
Project/Area Number |
19K10603
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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Research Institution | Sapporo Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
小林 宣道 札幌医科大学, 医学部, 教授 (80186759)
漆原 範子 札幌医科大学, 医学部, 准教授 (80396308)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | Streptococus / 肺炎球菌 / 蛋白結合型ワクチン / 血清型 / 無莢膜型 / 分子疫学 / 薬剤耐性 |
Outline of Final Research Achievements |
Among 4463 non-invasive S. pneumoniae isolates collected from outpatients who visited hospitals and clinics throughout Hokkaido between 2011 and 2019, 71 nonencapsulated Streptococcus pneumoniae (NESp) isolates were identified. All the NESp isolates were harbored pspK (94.4%) or aliC/aliD (5.6%). Five dominant sequence types (STs) were ST7502 (23.9%), ST4845 (19.7%), ST16214 (11.3%), ST11379 (9.9%), and ST7786 (7.0%), accounting for 71.8% of all isolates. Among all isolates, 67.6% were not susceptible to penicillin. Overall, multiple drug resistance which represents resistance to three or more different antimicrobial classes was detected in 88.7% of all isolates.
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Free Research Field |
衛生学 微生物学
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Academic Significance and Societal Importance of the Research Achievements |
小児に対する肺炎球菌結合型ワクチンが世界的に普及した現在において、現行のワクチンで予防できない「無莢膜型の増加」が示唆されている。この状況から、本研究では無莢膜型株の分子疫学的特徴およびその薬剤耐性を明らかにすることで、肺炎球菌感染症対策に寄与する知見を得ることを目的とした。分子疫学的・遺伝学的性状の解析は新規ワクチン開発に寄与する可能性を有する研究であり、グローバルな肺炎球菌感染症対策にも貢献できると考える。
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